Timing-Driven High-Level Synthesis for Continuous-Flow Microfluidic Biochips

ZhengYang Ye1, Zhisheng Chen2, Youlin Pan3, Genggeng Liu3, Wenzhong Guo3, Tsung-Yi Ho4, Xing Huang5
1Fuzhou University, 2Xiamen University´╝î Xiamen, 3Fuzhou University, Fuzhou, 4Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong, 5School of Computer Science, Northwestern Polytechnical University, Xi'an


Abstract

As continuous-flow microfluidic biochips technology rapidly advances, its automated synthesis methods require adapting to increasingly complex and stringent biochemical applications. In particular, with the introduction of time-sensitive bioassays, in this work, we present a timing-driven high-level synthesis method to optimize the resource efficiency of bioassays considering the time constraints. Specifically, we investigate the existing forms of time constraints and propose a corresponding flexible modeling approach based on reaction-control which can achieve downward compatibility for physical design. Additionally, we also analyze the impact of storage and wash on time constraints. The experimental results show that our method achieves efficient execution and low devices cost while satisfying time constraints.